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The report finds that progress toward reducing deforestation from infrastructure, extractive industries, and basic-needs activities is slow. While some governments and companies have adopted policies and commitments, implementation is often weak, transparency is limited, and large-scale development projects continue to threaten intact forests. The report emphasizes the need for a paradigm shift toward alternative development pathways and the empowerment of Indigenous peoples and local communities.

A study by the Climate Policy Initiative and PUC-Rio finds that the Manaus Free Trade Zone (ZFM) has not resulted in efficiency gains for the region's industries. Despite significant tax expenditures—reaching R$ 27.8 billion for ZFM, Western Amazon, and Free Trade Areas in 2015—both energy and productive efficiency levels in the ZFM remained similar to the national average from 2003 to 2015. This lack of impact persists even in the most representative sectors, such as two-wheel vehicle production and audio and video, where tax benefits are most concentrated.

The LUCIA project developed a computational Agent-Based Model (MBA) to simulate malaria transmission by accounting for the interactions between mosquitoes, parasites, and humans. Validated in regions of Brazil, Ecuador, and Peru, the model demonstrates that land-use changes—such as deforestation, mining, and agricultural expansion—combined with climate factors like river flooding, increase human vulnerability to malaria. Findings indicate that risk is higher for isolated homes on the outskirts of populations compared to central areas. The research suggests that managing larval breeding sites within 200 meters of populations can eliminate disease transmission, and notes that Ecuador has already modified its mining policies as a result.