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The Mekong River basin is the world's most productive inland fishery and the third most species-rich river for fish, hosting 1,148 recognized species. However, nearly 20% of these species are threatened with extinction due to hydropower dams, habitat loss, sand mining, pollution, and climate change. The report highlights the critical role of fish in regional food security—providing over half of the animal protein for many Lower Mekong populations—and their economic value in aquaculture, the aquarium trade, and potential eco-tourism. To reverse these declines, the document proposes a six-pillar Emergency Recovery Plan focusing on natural river flow, water quality, habitat restoration, sustainable resource management, control of invasive species, and the removal of obsolete barriers.

The study examines the drivers of hydrological alteration in the Srepok River Basin, finding that land use, rainfall, and temperature each affect different hydrological parameters. It identifies the 'fall rate' as the parameter most significantly affected by all three drivers, while hydropower development specifically impacts the fall rate and reversal.

The policy brief contends that climate risks are often 'borderless' and that treating adaptation as a local problem hinders global ambition. It advocates for a shared terminology and a transboundary framing of risk—recognizing how impacts in one country create risks in others via trade, migration, and ecosystems—to better utilize the Paris Agreement's mechanisms, such as the global stocktake and National Adaptation Plans, for collective resilience.

The report examines hydropower planning in the Se San and Sre Pok Basins, highlighting a persistent gap between progressive regional policies—such as those of the Mekong River Commission (MRC)—and the actual practice of site selection, which remains driven by national economic interests and technical-economic feasibility. It argues that while the 1995 MRC Agreement provides a legal framework, genuine environmental governance requires a transition from project-based to programme-based approaches that incorporate local perspectives and transboundary impact assessments. The study uses the Yali Falls Dam incident as a critical example of governance failure and a potential catalyst for improved conflict resolution and information sharing.

The document presents a series of supplemental tables mapping the climate change adaptation landscape in ASEAN countries. It identifies key decision-making bodies, such as Cambodia's National Climate Change Committee and Vietnam's National Committee of Climate Change, and lists guiding policies like the Thailand Climate Change Master Plan 2013–2050. The tables also catalogue agricultural research efforts, including the CGIAR Research Program on Climate Change Agriculture and Food Security, and detail funding sources, noting a heavy reliance on external donors in countries like Cambodia and Myanmar, while highlighting specific financial constraints in Malaysia.

The document examines water scarcity in the Mekong Region, highlighting a governance structure often dominated by top-down authority and a lack of enforceable water allocation rights. It notes that urban and industrial needs are typically prioritized over agriculture, leaving vulnerable groups—particularly women and the rural poor—at higher risk. The briefing also discusses the influence of international financial institutions and political motivations on irrigation infrastructure and the projected impacts of climate change, including increased temperature and seasonal rainfall uncertainty, which threaten agricultural productivity and food security.