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This report by the Climate and Development Knowledge Network (CDKN) synthesises seven years of experience in promoting 'climate compatible development'—an approach that integrates climate mitigation and adaptation with poverty eradication and human development. The document provides a framework for mainstreaming climate concerns into national macroeconomic planning, sectoral policies, and local governance, while emphasizing the necessity of political leadership, cross-government coordination, and inclusive stakeholder engagement. It details the financial challenges of transitioning to a low-carbon economy, the role of 'knowledge brokers' in translating science for policy-makers, and the importance of gender-sensitive implementation to ensure equitable outcomes.