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The proposed Donlin Gold Mine in Southwest Alaska, described as the world's largest pure gold mine, faces significant opposition from Indigenous Tribes and legal challenges from Earthjustice. The project involves a massive open-pit mine and a 316-mile gas pipeline, which opponents argue threatens critical subsistence resources, including salmon and rainbow smelt, and risks tailings dam failure. Legal actions are currently targeting state permits and a federal environmental impact statement to potentially vacate authorizations and force a project redesign.

Tribal governments from the Kuskokwim River region are challenging the Donlin Gold mine, which would be one of the world's largest open-pit mines. The project is opposed due to threats to the subsistence lifestyle of the Yukon Kuskokwim River Delta and the potential for permanent damage to water, fish, and game resources.