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The study identifies fuel type, kitchen volume, cooking methods, and ventilation as the primary drivers of in-kitchen particulate matter exposure in low-income homes across 12 global cities. The highest concentrations were found in Dhaka, driven by small kitchen size and extensive frying, while the lowest were in Medellín. The research highlights that charcoal use significantly increases PM2.5 levels compared to natural gas or LPG, and that dual ventilation (mechanical and natural) is more effective at reducing pollutants than natural ventilation alone.