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The document synthesises INC member inputs regarding the protection of human health within the framework of a proposed global plastics treaty. It highlights a broad consensus that the treaty's objectives should encompass both environmental and human health protections, noting that plastic pollution causes wide-ranging health issues, including neurotoxic and endocrine-disrupting impacts. The briefing details the work of two expert groups: Expert Group 1, focusing on financial mechanisms and means of implementation to mitigate health costs, and Expert Group 2, focusing on science-based criteria for identifying chemicals of concern, problematic products, and safe product design. Key priorities identified include the prevention of 'regrettable substitution' of chemicals, the necessity of material transparency, and the importance of protecting vulnerable populations, such as waste workers and indigenous peoples.