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The briefing identifies that city governments could reduce annual GHG emissions by up to 8 Gt CO2e by 2050 through coordinated action with national governments. It proposes a framework where cities lead in areas like spatial planning and transit (20% of potential), implement national standards in buildings (40%), and act as strategic partners for technology adoption like electric vehicles and solar PV (40%). The report emphasizes that national governments must remove financial, technical, and legal constraints to unlock this potential, providing specific examples of opportunities in China, the United States, and Brazil.