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The report identifies significant knowledge gaps hindering the achievement of the 2030 Agenda and argues that research must play four roles: characterizing challenges, providing solutions, coordinating dialogue, and critically analyzing the goals. Using SDGs 12, 14, and 17 as examples, it highlights the need for more applied 'action research' and a deeper understanding of goal interactions and international spill-over effects. The authors propose a tiered approach to structural reform, ranging from incremental improvements in open data and communication to transformative changes such as funding research led by third countries and reorienting the innovation system away from incremental economic growth toward social and climate justice.