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The report details the first ten years of the Inter-American Institute for Global Change Research (IAI), outlining its mission to understand global environmental changes in the Americas. It describes the evolution of its scientific agenda from seven initial themes to four broad categories, the implementation of various grant programs (Initial Grants, Initial Scientific Program, and Cooperative Research Networks), and the establishment of its headquarters in Brazil. Key achievements include the funding of 14 Cooperative Research Networks (CRNs) with a US$10 million investment, the training of hundreds of scientists and students, and the creation of the IAI-DIS data system. The document also lists specific research projects focusing on climate variability, biodiversity, and human dimensions across North, Central, and South America.