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The report argues that political, ideological, and financial interests have undermined science in US federal decision making, harming public health and environmental protections. It defines scientific integrity as the practice where independent science, free from undue influence, informs policy transparently. To address persisting issues such as political interference and barriers to information flow, the document proposes a comprehensive blueprint for the next administration. Key recommendations include appointing a respected science advisor with direct access to the president, establishing a dedicated assistant director for scientific integrity within the Office of Science and Technology Policy (OSTP), and requiring agencies to appoint scientific integrity officials who report publicly on violations. The report also calls for strengthening whistleblower protections, reforming the federal scientific advisory committee system to increase transparency, and ensuring that the Office of Management and Budget (OMB) does not override agency scientific expertise. Additionally, it suggests enhancing public participation in rulemaking through better technology and strengthening environmental justice requirements by making scientific analysis of equity consequences mandatory for significant rules.