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The report argues that pandemic prevention must shift from a human-centric biosecurity model to a holistic 'One Health' approach that integrates ecological security. It identifies critical gaps, such as funding silos between human and animal health research and a lack of sociological context in interventions. The document details U.S. agency efforts—including those by the USGS, FWS, and USAID—and proposes a project lifecycle for spillover prevention that emphasizes multidisciplinary teams, community engagement, and standardized data practices. It specifically highlights how deforestation, illicit wildlife trade, and industrial animal husbandry increase spillover risks, and recommends treating conservation as a national security imperative.